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Current Studies

Our researchers recently completed the largest genome-wide association study (GWAS) to date looking at millions of single nucleotide polymorphisms (SNPs) for genetic evidence of disease susceptibility in a small group of ME patients.   After identifying the most relevant SNPs in this study, they intend to collect a much larger number of samples for a more directed search and confirmation of their original findings.  Understanding vulnerability to a disease can help point the way toward more effective treatments and possible prevention.
There are signs that autoimmunity may play a role in ME.  Our researchers are working with researchers from Arizona State University and the Canadian health system to identify autoimmune markers of disease.   These findings will help doctors understand the underlying causes of disease and may assist the NIH when deciding the appropriate placement of this disease for future study.
Our researchers discovered that specialized immune cells, called plasmacytoid dendritic cells or pDCs, infiltrate the gut tissue of ME patients more than three-fold when compared to control subjects.  Our ongoing research is exploring the significance of these observations in the context of neuro-immune disease disease and the gut-brain axis.
Our researchers found an inflammatory cytokine, CCL27, to be associated with MS.  CCL-27 has been identified as a marker for eczema and may play a crucial role in T cell-mediated inflammation. Our researchers are interested in learning how MS is triggered to help prevent the disease from occurring.  In addition to immune deficits, our researchers are studying other key pathways as possible triggers of disease. Dr. Khaiboullina has begun studies of MS using neuronal cell lines and will soon be working with neurologists in the U.S. and Russia as she continues her unique study of various immunological pathways in MS.

Our goal is to discover markers of abnormal innate immune responses and autoimmunity that will lead to effective biological treatments for patients with ASD.

Diseases

Our purpose is to improve the diagnosis, prevention, and treatment of diseases that place a significant burden on the global community.

Myalgic Encephalomyelitis
Myalgic EncephalomyelitisChronic Fatigue Syndrome
Myalgic encephalomyelitis, also referred to as Chronic Fatigue Syndrome, is a complex disease involving profound dysregulation of the central nervous system and immune system. This systemic disease is characterized by severe flu-like symptoms, accompanied by a substantial loss of stamina and energy. read more
Autism Spectrum Disorder
Autism Spectrum DisorderGroup of Developmental Disorders
Autism spectrum disorder is a general term for a group of complex disorders of brain development. Those impacted experience severe deficits of higher mental functions such as social interaction, verbal and non-verbal communication skills, imagination, and cognition. read more

Multiple Sclerosis
Multiple SclerosisDisease of the Central Nervous System
Multiple sclerosis is an unpredictable, often disabling, disease that disrupts the flow of information within the central nervous system. The most common symptoms are overwhelming fatigue, visual disturbances, altered sensation, and difficulties with mobility. read more
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Scientific Advisory Board

Kenneth Hunter Jr.
Kenneth Hunter Jr. SC.D., SAB CHAIR University of Nevada, Reno
Department of Microbiology and Immunology
Applied Research Facility (ARF), Room 412
Mail Stop 199
1664 North Virginia Street
Reno, NV 89557
(775) 327-5255
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Petar Lenart
Petar Lenart M.D., M.SC., PH.D. Clinical Associate Professor,
Internal Medicine
University of Iowa Hospitals and Clinics
200 Hawkins Drive
Iowa City, IA 52242
Phone: 800-777-8442
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Ron Pardini
Ron PardiniPH.D. University of Nevada, Reno
Molecular Biosciences
Max Fleischmann Agriculture Building 210
Mail Stop: 0221
1664 North Virginia Street
Reno, NV 89557
(775) 784-6237
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