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Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis.

Authors: Khaiboullina SF, DeMeirleir KL, Rawat S, Berk GS, Gaynor-Berk RS, Mijatovic T, Blatt N, Rizvanov AA, Young SG, Lombardi VC. Link: http://www.ncbi.nlm.nih.gov/pubmed/25514671 Publication: Cytokine. 2015 Mar;72(1):1-8. doi: 10.1016/j.cyto.2014.11.019. Epub 2014 Dec 13. Gulf War illness (GWI) is a chronic disease of unknown etiology characterized by persistent symptoms such as cognitive impairment, unexplained fatigue, pervasive [...]

By | May 20th, 2016|Publications|0 Comments

Plasmacytoid dendritic cells, a role in neoplastic prevention and progression.

Authors: Lombardi VC, Khaiboullina SF, Rizvanov AA. Link: http://www.ncbi.nlm.nih.gov/pubmed/25524580 Publication: Eur J Clin Invest. 2015 Jan;45 Suppl 1:1-8. doi: 10.1111/eci.12363. BACKGROUND: Plasmacytoid dendritic cells (pDCs) are multifunctional bone-marrow-derived immune cells that are key players in bridging the innate and adaptive immune systems. Activation of pDCs through toll-like receptor agonists has proven to be an effective [...]

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Erythrocyte: A systems model of the control of aggregation and deformability.

Authors: Bazanovas AN, Evstifeev AI, Khaiboullina SF, Sadreev II, Skorinkin AI, Kotov NV. Link: http://www.ncbi.nlm.nih.gov/pubmed/25805555 Publication: Biosystems. 2015 May;131:1-8. doi: 10.1016/j.biosystems.2015.03.003. Epub 2015 Mar 21. Human erythrocytes are highly specialized enucleate cells that are involved in providing efficient gas transport. Erythrocytes have been extensively studied both experimentally and by mathematical modeling in recent years. However, [...]

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Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica.

Authors: Baigildina AA, Khaiboullina SF, Martynova EV, Anokhin VA, Lombardi VC, Rizvanov AA. Link: http://www.ncbi.nlm.nih.gov/pubmed/25313675 Publication: Biomark Med. 2015;9(2):99-107. doi: 10.2217/bmm.14.88. Epub 2014 Oct 14. AIMS: Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated with the Puumala virus species of Hantavirus. The pathogenesis of NE is not well understood; therefore, [...]

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Upregulation of IFN-γ and IL-12 is associated with a milder form of hantavirus hemorrhagic fever with renal syndrome.

Authors: Khaiboullina SF, Martynova EV, Khamidullina ZL, Lapteva EV, Nikolaeva IV, Anokhin VV, Lombardi VC, Rizvanov AA. Link: http://www.ncbi.nlm.nih.gov/pubmed/24942310 Publication: Eur J Clin Microbiol Infect Dis. 2014 Dec;33(12):2149-56. doi: 10.1007/s10096-014-2176-x. Epub 2014 Jun 19. Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease characterized by acute onset, fever, malaise, and back pain. As [...]

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Differential immuno-reactivity to genomic DNA, RNA and mitochondrial DNA is associated with auto-immunity.

Authors: Ivanova VV, Khaiboullina SF, Cherenkova EE, Martynova EV, Nevzorova TA, Kunst MA, Sibgatullin TB, Maksudova AN, Oliveira PJ, Lombardi VC, Palotás A, Rizvanov AA. Link: http://www.ncbi.nlm.nih.gov/pubmed/25562166 Publication: Cell Physiol Biochem. 2014;34(6):2200-8. doi: 10.1159/000369663. Epub 2014 Dec 4. BACKGROUND: Circulating auto-reactive antibodies are hallmark features of auto-immune diseases, however little is known with respect to [...]

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CCL27: Novel Cytokine with Potential Role in Pathogenesis of Multiple Sclerosis

Authors: Svetlana F. Khaiboullina, Aigul R. Gumerova, Irina F. Khafizova, Ekaterina V. Martynova, Vincent C. Lombardi, Saverio Bellusci, and Albert A. Rizvanov Link: http://www.hindawi.com/journals/bmri/aa/189638/ Publication: BioMed Research International Article ID 189638 Received 7 November 2014; Accepted 11 December 2014 Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease of unknown etiology. Leukocyte infiltration of brain [...]

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Plasmacytoid dendritic cells of the gut: Relevance to immunity and pathology

Authors: Vincent C. Lombardi, Svetlana F. Khaiboullina Link: http://www.sciencedirect.com/science/article/pii/S1521661614001144 Publication: Clinical Immunology Volume 153, Issue 1, July 2014, Pages 165–177 Plasmacytoid dendritic cells (pDCs) are bone marrow-derived immune cells with the ability to express copious amounts of type I and III interferon (IFN) and can differentiate into antigen-presenting dendritic cells as a result of stimulation [...]

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Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis

Authors: Svetlana F. Khaiboullina, Kenny L. DeMeirleir, Shanti Rawat, Grady S. Berk, Rory S. Gaynor-Berk, Tatjana Mijatovic, Natalia Blatt, Albert A. Rizvanov, Sheila G. Young, Vincent C. Lombardi Link: http://www.sciencedirect.com/science/article/pii/S1043466614006024 Publication: Cytokine Volume 72, Issue 1, March 2015, Pages 1–8 Gulf War illness (GWI) is a chronic disease of unknown etiology characterized by persistent symptoms [...]

By | May 20th, 2016|Publications|0 Comments

Death-domain associated protein-6 (DAXX) mediated apoptosis in hantavirus infection is counter-balanced by activation of interferon-stimulated nuclear transcription factors.

Authors: Khaiboullina SF, Morzunov SP, Boichuk SV, Palotás A, St Jeor S, Lombardi VC, Rizvanov AA. Link: http://www.ncbi.nlm.nih.gov/pubmed/23830076 Publication: Virology. 2013 Sep 1;443(2):338-48. doi: 10.1016/j.virol.2013.05.024. Epub 2013 Jul 3. Hantaviruses are negative strand RNA species that replicate predominantly in the cytoplasm. They also activate numerous cellular responses, but their involvement in nuclear processes is yet [...]

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