Publications

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The Skin–Brain Connection Hypothesis, Bringing Together CCL27-Mediated T-Cell Activation in the Skin and Neural Cell Damage in the Adult Brain

Authors: Nataliya L. Blatt, Timur I. Khaiboullin,Vincent C. Lombardi, Albert A. Rizvanov and Svetlana F. Khaiboullina1, Link: http://journal.frontiersin.org/article/10.3389/fimmu.2016.00683/full Publication: Front. Immunol., 16 January 2017 Recent discovery of an association of low serum melatonin levels with relapse in multiple sclerosis (MS) opens a new horizon in understanding the pathogenesis of this disease. Skin is the main organ [...]

By | January 17th, 2017|NewsAndEvents, Publications|0 Comments

Humoral Immunity Profiling of Subjects with MyalgicEncephalomyelitis Using a Random Peptide MicroarrayDifferentiates Cases from Controls with High Specificityand Sensitivity

Authors: Sahajpreet Singh, Phillip Stafford, Karen A. Schlauch, Richard R. Tillett, Martin Gollery, Stephen Albert Johnston, Svetlana F. Khaiboullina, Kenny L. De Meirleir, Shanti Rawat, Tatjana Mijatovic, Krishnamurthy Subramanian, András Palotás, Vincent C. Lombardi Link: http://bit.ly/2h55uXC Publication: Mol Neurobiol (DOI 10.1007/s12035-016-0334-0) Abstract Myalgic encephalomyelitis (ME) is a complex, heterogeneous illness of unknown etiology. The search for biomarkers that can delineate [...]

By | December 15th, 2016|NewsAndEvents, Publications|0 Comments

Failure of gut-associated pDCs to express membrane bound APRIL and BAFF prevents their ability to promote low-affinity IgA expression in ME/CFS

Authors: Vincent C Lombardi, Svetlana F Khaiboullina, Kenny L De Meirleir, Tanja Mijatovic, Jan Hulstaer Link: http://www.jimmunol.org/content/196/1_Supplement/137.4 Publication: The Journal of Immunology (2016) Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a heterogeneous illness characterized by a number of comorbid conditions; gastrointestinal (GI) dysregulation make up one subgroup of this disease. IgA is the most abundant antibody isotype found in mucosal secretions including [...]

By | October 10th, 2016|Publications|0 Comments

Decreased Numbers of CD57+CD3− Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder

Authors: Siniscalco D, Mijatovic T, Bosmans E, Cirillo A, Kruzliak P, Lombardi VC, DE Meirleir K, Antonucci N Link: https://www.ncbi.nlm.nih.gov Publication: in vivo (2016) Background. Autism spectrum disorders (ASD) are complex, and severe heterogeneous neurodevelopmental pathologies with accepted but complex immune system abnormalities. Additional knowledge regarding potential immune dysfunctions may provide a greater understanding of [...]

By | October 10th, 2016|Publications|0 Comments

Transcriptional Analysis of Blood Lymphocytes and Skin Fibroblasts, Keratinocytes, and Endothelial Cells as a Potential Biomarker for Alzheimer’s Disease.

Authors: Mukhamedyarov MA, Rizvanov AA, Yakupov EZ, Zefirov AL, Kiyasov AP, Reis HJ, Teixeira AL, Vieira LB, Lima LM, Salafutdinov II, Petukhova EO, Khaiboullina SF, Schlauch KA, Lombardi VC, Palotás A. Link: https://www.ncbi.nlm.nih.gov/pubmed/27589530 Publication: J Alzheimers Dis. 2016 Sep 2. [Epub ahead of print] Alzheimer's disease (AD) is a devastating and progressive form of dementia [...]

By | October 10th, 2016|Publications|0 Comments

Hantavirus Infection Suppresses Thrombospondin-1 Expression in Cultured Endothelial Cells in a Strain-Specific Manner.

Authors: Khaiboullina SF, Morzunov SP, St Jeor SC, Rizvanov AA, Lombardi VC. Link: https://www.ncbi.nlm.nih.gov/pubmed/27486439 Publication: Front Microbiol. 2016 Jul 19;7:1077. doi: 10.3389/fmicb.2016.01077. eCollection 2016. Hantavirus infection is associated with two frequently fatal diseases in humans: Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The pathogenesis of hantavirus infection is complex and not fully [...]

By | October 10th, 2016|Publications|0 Comments

Genome-wide association analysis identifies genetic variations in subjects with myalgic encephalomyelitis/chronic fatigue syndrome

Authors: KA Schlauch1, SF Khaiboullina2,3, KL De Meirleir2, S Rawat2, J Petereit1, AA Rizvanov3, N Blatt3, T Mijatovic4, D Kulick5, A Palotás3,6 and VC Lombardi1,2 Link: http://www.ncbi.nlm.nih.gov/pubmed/26859813 | http://www.nature.com/tp/journal/v6/n2/pdf/tp2015208a.pdf Publication: Citation: Transl Psychiatry (2015) 6, e●●; doi:10.1038/tp.2015.208 Myalgic encephalomyelitis, also known as chronic fatigue syndrome or ME/CFS, is a multifactorial and debilitating disease that has [...]

By | May 20th, 2016|Publications|0 Comments

Gut-Associated Plasmacytoid Dendritic Cells Display an Immature Phenotype and Upregulated Granzyme B in Subjects with HIV/AIDS

Authors: Sergei V. Boichuk,1,† Svetlana F. Khaiboullina,2,3,† Bulat R. Ramazanov,1 Gulshat R. Khasanova,1 Karina A. Ivanovskaya,4 Evgeny Z. Nizamutdinov, Marat R. Sharafutdinov, Ekaterina V. Martynova, Kenny L. DeMeirleir, Jan Hulstaert, Vladimir A. Anokhin, Albert A. Rizvanov, and Vincent C. Lombardi Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585323/ Publication: Frontiers in Immunology Front Immunol. 2015; 6: 485. Published online 2015 Sep [...]

By | May 20th, 2016|Publications|0 Comments

Multiplex Analysis of Serum Cytokines in Humans with Hantavirus Pulmonary Syndrome.

Authors: Morzunov SP, KhaiboullinSF, St Jeor S, Rizvanov AA, Lombardi VC. Link: http://www.ncbi.nlm.nih.gov/pubmed/26379668 Publication: Frontiers in Immunology Front Immunol. 2015 Aug 31;6:432. doi: 10.3389/fimmu.2015.00432. eCollection 2015. Hantavirus pulmonary syndrome (HPS) is an acute zoonotic disease transmitted primarily through inhalation of virus-contaminated aerosols. Hantavirus infection of endothelial cells leads to increased vascular permeability without a visible [...]

By | May 20th, 2016|Publications|0 Comments

Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis.

Authors: Khaiboullina SF, DeMeirleir KL, Rawat S, Berk GS, Gaynor-Berk RS, Mijatovic T, Blatt N, Rizvanov AA, Young SG, Lombardi VC. Link: http://www.ncbi.nlm.nih.gov/pubmed/25514671 Publication: Cytokine. 2015 Mar;72(1):1-8. doi: 10.1016/j.cyto.2014.11.019. Epub 2014 Dec 13. Gulf War illness (GWI) is a chronic disease of unknown etiology characterized by persistent symptoms such as cognitive impairment, unexplained fatigue, pervasive [...]

By | May 20th, 2016|Publications|0 Comments