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Monthly Archives: May 2016

Plasmacytoid dendritic cells of the gut: Relevance to immunity and pathology

Authors: Vincent C. Lombardi, Svetlana F. Khaiboullina Link: http://www.sciencedirect.com/science/article/pii/S1521661614001144 Publication: Clinical Immunology Volume 153, Issue 1, July 2014, Pages 165–177 Plasmacytoid dendritic cells (pDCs) are bone marrow-derived immune cells with the ability to express copious amounts of type I and III interferon (IFN) and can differentiate into antigen-presenting dendritic cells as a result of stimulation [...]

By | May 20th, 2016|Publications|0 Comments

Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis

Authors: Svetlana F. Khaiboullina, Kenny L. DeMeirleir, Shanti Rawat, Grady S. Berk, Rory S. Gaynor-Berk, Tatjana Mijatovic, Natalia Blatt, Albert A. Rizvanov, Sheila G. Young, Vincent C. Lombardi Link: http://www.sciencedirect.com/science/article/pii/S1043466614006024 Publication: Cytokine Volume 72, Issue 1, March 2015, Pages 1–8 Gulf War illness (GWI) is a chronic disease of unknown etiology characterized by persistent symptoms [...]

By | May 20th, 2016|Publications|0 Comments

Death-domain associated protein-6 (DAXX) mediated apoptosis in hantavirus infection is counter-balanced by activation of interferon-stimulated nuclear transcription factors.

Authors: Khaiboullina SF, Morzunov SP, Boichuk SV, Palotás A, St Jeor S, Lombardi VC, Rizvanov AA. Link: http://www.ncbi.nlm.nih.gov/pubmed/23830076 Publication: Virology. 2013 Sep 1;443(2):338-48. doi: 10.1016/j.virol.2013.05.024. Epub 2013 Jul 3. Hantaviruses are negative strand RNA species that replicate predominantly in the cytoplasm. They also activate numerous cellular responses, but their involvement in nuclear processes is yet [...]

By | May 20th, 2016|Publications|0 Comments

Biological insight, high-throughput datasets and the nature of neuro-degenerative disorders.

Authors: Valente AX, Oliveira PJ, Khaiboullina SF, Palotás A, Rizvanov AA. Link: http://www.ncbi.nlm.nih.gov/pubmed/23937175 Publication: Curr Drug Metab. 2013 Sep;14(7):814-8. Life sciences are experiencing a historical shift towards a quantitative, data-rich regime. This transition has been associated with the advent of bio-informatics: mathematicians, physicists, computer scientists and statisticians are now commonplace in the field, working on [...]

By | May 20th, 2016|Publications|0 Comments

Human dendritic cells transfected with a human papilloma virus-18 construct display decreased mobility and upregulated cytokine production.

Authors: Khaiboullina SF, Morzunov SP, Hall MR, De Meirleir KL, Rizvanov AA, Lombardi VC. Link: http://www.ncbi.nlm.nih.gov/pubmed/23969559 Publication: Int J Oncol. 2013 Nov;43(5):1701-9. doi: 10.3892/ijo.2013.2074. Epub 2013 Aug 21. The marked depletion of dendritic cells (DCs) in skin cancers, as well as preneoplastic and neoplastic cervical epithelium, suggests a central role for DCs in productive human [...]

By | May 20th, 2016|Publications|0 Comments

Andes-virus-induced cytokine storm is partially suppressed by ribavirin.

Authors: Khaiboullina SF, Rizvanov AA, Lombardi VC, Morzunov SP, Reis HJ, Palotás A, St Jeor S. Link: http://www.ncbi.nlm.nih.gov/pubmed/23300158 Publication: Antivir Ther. 2013;18(4):575-84. doi: 10.3851/IMP2524. Epub 2013 Jan 8. BACKGROUND: Microbe-induced over-activation of cytokines, especially tumour necrosis factor (TNF)-α, is key to the pathogenesis of hantavirus infection leading to severe inflammation with high mortality rate. Although [...]

By | May 20th, 2016|Publications|0 Comments

Screening Models of Anticancer Drugs

Authors: Natalia L. Blatt, Rimma N. Mingaleeva, Svetlana F. Khaiboullina, Alexander Kotlyar, Vincent C. Lombardi, Albert A. Rizvanov* Link: http://www.lifesciencesite.com/lsj/life1004/250_21662life1004_1892_1900.pdf Publication: Life Science Journal 2013;10(4) Abstract: Animal models have been indispensable when conducting research to further the understanding of cancer biology and when developing anticancer drugs. This article presents an overview of the most commonly [...]

By | May 20th, 2016|Publications|0 Comments

Application of Cell and Tissue Culture Systems for Anticancer Drug Screening

Authors:1Natalia L. Blatt, 1Rimma N. Mingaleeva, 2Svetlana F. Khaiboullina, 2Vincent C. Lombardi and 1Albert A. Rizvanov Link: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.388.1986&rep=rep1&type=pdf Publication: WASJ Abstract: A primary reason why potential anticancer drugs fail in clinical trials is the limitations of existing in vitro screening systems. The purpose of in vitro testing is to aid in the selection of efficacious [...]

By | May 20th, 2016|Publications|0 Comments

Cheers Event

Join Nevada Center for Biomedical Research (NVCBR) in support of scientific discovery and treat yourself to an entertaining evening at the Nevada Museum of Art!

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By | May 13th, 2016|NewsAndEvents|0 Comments

Plasmacytoid dendritic cells in the duodenum of individuals diagnosed with myalgic encephalomyelitis are uniquely immunoreactive to antibodies to human endogenous retroviral proteins.

Authors: De Meirleir KL, Khaiboullina SF, Frémont M, Hulstaert J, Rizvanov AA, Palotás A, Lombardi VC Link: http://www.ncbi.nlm.nih.gov/pubmed/23422476 Publication: In Vivo. 2013 Mar-Apr;27(2):177-87. Myalgic encephalomyelitis (ME) is a debilitating illness of unknown etiology characterized by neurocognitive dysfunction, inflammation, immune abnormalities and gastrointestinal distress. An increasing body of evidence suggests that disruptions in the gut may [...]

By | May 12th, 2016|Publications|0 Comments